Jeffrey A. Pleiss

A topologically conserved unstructured region helps positioning the evolutionarily conserved Prp40 WW domains to promote non-canonical intron splicing

This paper identifies a conserved unstructured region in Prp40 WW domains that facilitates their positioning to promote non-canonical intron splicing in yeast.

Machine learning-optimized targeted detection of alternative splicing

This paper introduces LSV-seq, a targeted RNA-seq method optimized with machine learning to detect alternative splicing with high sensitivity and low sequencing depth.

Transcript-specific determinants of pre-mRNA splicing revealed through in vivo kinetic analyses of the 1st and 2nd chemical steps

The paper measures in vivo rates of the first and second chemical steps of pre-mRNA splicing across the genome and identifies splice site sequences and ribosomal protein gene features as key determinants of splicing rates.

High Precision Detection of Rare Splice Isoforms Using Multiplexed Primer Extension Sequencing

The paper introduces a targeted RNA-sequencing method using complex primer pools to detect rare splice isoforms with high precision.