PathologyCirculationPeer-reviewed
Loss of the Coronary Artery Disease Risk Gene Leiomodin1 in Vascular Smooth Muscle Cells Triggers Rapid Onset Coronary Atherosclerosis
Amr R. Salem, Ajay Kumar, Jaser Doja…·Joseph M. Miano
This study shows that loss of Leiomodin1 in vascular smooth muscle cells causes rapid coronary atherosclerosis in mice, independent of actin nucleation, and highlights Thbs1 as a target for mitigating foam cell formation.