Lei P. Wang

A Shifting Immune Landscape: ILC Redistribution and Neutrophil Polarization in Vascular Cognitive Impairment and Dementia (VCID)

This study investigates how vascular dysfunction in VCID affects innate immune cells, finding compartment-specific ILC redistribution and pro-inflammatory neutrophil polarization in the brain.

Targeting a Granulocytic/Microbiome Axis Reverses Glioblastoma Progression via Intranasal Cannabidiol

This study identifies a neuro-immune-microbiome axis in glioblastoma that can be targeted by intranasal cannabidiol to reverse tumor progression.

Adoptive Transfer of ILC2s into the Brain Reveals Tumor Homing in Glioblastoma: A Proof-of-Concept for Cellular Therapy

This study shows that ILC2s can cross the BBB and home to glioblastoma tumors in mice, supporting adoptive transfer as a potential strategy for targeting CNS tumors.

Protective role of Cannabidiol against nicotine pouch-induced seizure aggravation and alterations in brain glymphatic biomarkers.

This study shows that chronic nicotine pouch exposure worsens seizures and glymphatic function in mice, but inhaled CBD reverses these effects.

Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control

This study investigates how cannabidiol affects IDO and cGAS pathways in Alzheimer's disease using a mouse model, finding reduced inflammation and cytokine levels.

Optimization of Seizure Prevention by Cannabidiol (CBD)

This study evaluates the effectiveness of different CBD formulations and delivery routes in reducing seizure severity in a mouse model of epilepsy, finding inhaled broad-spectrum CBD to be most effective.