Joseph M. Miano

This study shows that loss of Leiomodin1 in vascular smooth muscle cells causes rapid coronary atherosclerosis in mice, independent of actin nucleation, and highlights Thbs1 as a target for mitigating foam cell formation.

This paper shows that cholesterol-loaded vascular smooth muscle cells (VSMCs) lose TGFβ signaling and contractile features, but HDL-mediated cholesterol efflux restores signaling and contractile markers.

This paper identifies INKILN, a human-specific lncRNA that promotes vascular smooth muscle inflammation by stabilizing MKL1 and interacting with USP10.

This paper compares two CreERT2 mice, showing Itga8-CreERT2 avoids a lethal intestinal phenotype seen with Myh11-CreERT2 when knocking out Srf.

CRISPR-LRS maps transgene integration loci and estimates copy numbers in mice, aiding breeding and phenotyping.

This paper compares CRISPR-mediated HDR and PE2 systems in mice to show PE2's higher fidelity in editing a TFBS, leading to more effective tissue-specific gene inactivation.