Author

David R. Lynch

Children's Hospital of PhiladelphiaORCID 0000-0001-7168-214XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Brent L. FogeliD· 1 shared Clementina MesarosiD· 1 shared Darice Y. WongiD· 1 shared Hui LiiD· 1 shared Jacob An· 1 shared Jennifer Coulman· 1 shared Lucie Vanessa Ngaba· 1 shared Mert KokaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Brent L. FogelORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 14, 2026

Ketosis rescues frataxin deficiency and corrects disease phenotypes in an FRDA animal model

Yina Dong, Miniat W. Adeshina, Ryan Smith…·David R. Lynch

This study shows that ketosis increases frataxin levels and improves disease symptoms in a Friedreich ataxia mouse model.

DOI 10.64898/2026.01.14.699352

mouseproteomics

𝕏 PostBluesky

NeuroscienceBrain CommunicationsPeer-reviewedJan 1, 2024

Long non-coding RNA TUG1 is down-regulated in Friedreich's ataxia.

Mert Koka, Hui Li, Rumana Akther…·Vijayendran Chandran

This study identifies TUG1 as a blood-based biomarker for Friedreich's ataxia, showing its downregulation in patients and correlation with disease severity.

7 citations

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