Author

Ryan Smith

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Biochemistry· 1 Genetics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 4 Approach:statistical model· 4 Research Focus:benchmarking· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Varun Bhamidipati DwarakaiD· 4 shared Kirsten SealeiD· 3 shared Ilinca M. Giosan· 2 shared Adiv A. JohnsoniD· 1 shared Avshalom CaspiiD· 1 shared Clementina MesarosiD· 1 shared David R. LynchiD· 1 shared Dua Sheikh· 1 shared

Activity by Year

2026-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBioinformatics

Varun Bhamidipati DwarakaORCID

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Author profile →

5 papers

Recent·Most cited

SARDINE unlocks EWAS summary statistics for large-scale epigenetic biomarker analysis

Yuchang Wu, Yushan Wang, Ryan Moreno, Sarah M. Merrill, Varun Bhamidipati Dwaraka, Kirsten Blythe Seale, Ryan Smith, Lauren L Schmitz, Qiongshi Lu

SARDINE uses EWAS summary statistics to estimate epigenetic clock-phenotype associations without individual-level data, revealing heterogeneity in biomarker associations with aging and diseases.

bioRxiv · Nov 6, 2026 · PreprintGenetics

Whole-blood DNA-methylation patterns during portable-sauna use in firefighters: an exploratory, single-arm pilot study

Varun Bhamidipati Dwaraka, Adiv A. Johnson, Kirsten Seale, Nolan Kahal, Dua Sheikh, Sean Morrissey, Ryan Smith

This study examines how portable-sauna use affects DNA methylation in firefighters' whole blood, identifying potential epigenetic changes linked to aging and health.

bioRxiv · Sep 9, 2026 · PreprintPhysiology

Creating DNAm Algorithms Using the Illumina Methylation Screening Array (MSA)

Kirsten Seale, Sayf Al-Deen Hassouneh, Ilinca M. Giosan, Karen Sugden, Laura Balagué-Dobón, Varun Bhamidipati Dwaraka, Jessica Ann Lasky-Su, Mike Mallin, Avshalom Caspi, Terrie E. Moffitt, Ryan Smith, Natàlia Carreras-Gallo

The paper develops a reproducibility-based framework for creating DNA methylation algorithms on the MSA, showing that stable probe sets can support new biomarkers and transfer of existing ones with improved performance.

bioRxiv · Sep 4, 2026 · PreprintBioinformatics

Fasting Status and Epigenetic Clock Stability: Implications for Aging Research

Kirsten Seale, Varun Bhamidipati Dwaraka, Ilinca M. Giosan, Tavis L. Mendez, Ryan Smith

This study evaluates how epigenetic clocks respond to fasting and refeeding, finding that some clocks show significant shifts while others remain stable, highlighting the importance of immune cell composition and study design.

bioRxiv · Jun 7, 2026 · PreprintBioinformatics

Ketosis rescues frataxin deficiency and corrects disease phenotypes in an FRDA animal model

Yina Dong, Miniat W. Adeshina, Ryan Smith, Lucie Vanessa Ngaba, Jacob An, Olivia Seline, Jennifer Coulman, Shahd Al Haj Ali, Clementina Mesaros, Peining Jimmy Xu, David R. Lynch

This study shows that ketosis increases frataxin levels and improves disease symptoms in a Friedreich ataxia mouse model.

bioRxiv · Jan 14, 2026 · PreprintBiochemistry