Author

Shan Chang

Jiangsu University of TechnologyORCID 0000-0001-7169-9398Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

Dawei ZhangiD· 1 shared Ji WuiD· 1 shared Jun DingiD· 1 shared Lei XuiD· 1 shared Liangxu XieiD· 1 shared Mingjun YangiD· 1 shared Sen Yang· 1 shared Xiaohua LuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Dawei ZhangORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJul 28, 2026

ProtSyntax: a protein large language model for decoding post-translational modification syntax and function

Yiyu Lin, Ji Wu, You Zhou…·Sen Yang

ProtSyntax is a protein language model that improves PTM site prediction and functional inference by integrating contextual and structural information.

DOI 10.64898/2026.07.18.739331

protein sequencedeep learning

𝕏 PostBluesky

BioinformaticsbioRxivPreprintFeb 9, 2025

Predicting Mutation-Induced Relative Protein-Ligand Binding Affinity Changes via Conformational Sampling and Diversity Integration with Subsampled Alphafold2 in Few-Shot Learning

Liangxu Xie, Xiaohua Lu, Dawei Zhang…·Xiaojun Xu

The paper predicts mutation-induced changes in protein-ligand binding affinity using few-shot learning with AlphaFold2 subsampling and Siamese learning, achieving improved correlation on TKI datasets.

2 citations

protein structuredeep learning

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