Author

Liangxu Xie

Jiangsu University of TechnologyORCID 0000-0002-0609-5333Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Dawei ZhangiD· 1 shared Jun WangiD· 1 shared Lei XuiD· 1 shared Mingjun YangiD· 1 shared Qian-Yuan TangiD· 1 shared Shan ChangiD· 1 shared Weitong ReniD· 1 shared WenFei LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Dawei ZhangORCID

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2 papers

Recent·Most cited

Unifying constraints linking protein folding and native dynamics decoded from AlphaFold

Zecheng Zhang, Weitong Ren, Liangxu Xie, Yuxiang Zheng, Xingyue Guan, Jun Wang, WenFei Li, Qian-Yuan Tang

The paper analyzes AlphaFold-predicted structures to show a relationship between folding topology and native dynamics across species.

Physical Review Letters · Jan 20, 2026Peer-reviewedBioinformatics

Predicting Mutation-Induced Relative Protein-Ligand Binding Affinity Changes via Conformational Sampling and Diversity Integration with Subsampled Alphafold2 in Few-Shot Learning

Liangxu Xie, Xiaohua Lu, Dawei Zhang, Lei Xu, Mingjun Yang, Young-Seob Jeong, Shan Chang, Xiaojun Xu

The paper predicts mutation-induced changes in protein-ligand binding affinity using few-shot learning with AlphaFold2 subsampling and Siamese learning, achieving improved correlation on TKI datasets.

bioRxiv · Feb 9, 2025 · PreprintBioinformatics