BioinformaticsbioRxivPreprint
Predicting Mutation-Induced Relative Protein-Ligand Binding Affinity Changes via Conformational Sampling and Diversity Integration with Subsampled Alphafold2 in Few-Shot Learning
Liangxu Xie, Xiaohua Lu, Dawei Zhang…·Xiaojun Xu
The paper predicts mutation-induced changes in protein-ligand binding affinity using few-shot learning with AlphaFold2 subsampling and Siamese learning, achieving improved correlation on TKI datasets.
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