Molecular BiologyeLifePeer-reviewed
MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation
Rafael Romero-Becerra, Alfonso Mora, Elisa Manieri…·Guadalupe Sabio
This paper shows that MKK6 deficiency leads to cardiac dysfunction through hyperactivation of the MKK3-p38γ/δ-mTOR pathway, causing hypertrophy and fibrosis, and highlights potential cardiotoxicity of p38 inhibitors.
28 citations