David Filgueiras Rama

This study shows that antiarrhythmic drug efficacy in atrial fibrillation depends on patient-specific electrophysiological substrates and rotor dynamics, with drug-induced frequency reduction being a key mechanism.

The paper introduces PACREDOX, a redox proteomics method that improves efficiency and compatibility with DIA, quantifying thousands of proteins and modified peptides in myocardial tissue.

This paper shows that MKK6 deficiency leads to cardiac dysfunction through hyperactivation of the MKK3-p38γ/δ-mTOR pathway, causing hypertrophy and fibrosis, and highlights potential cardiotoxicity of p38 inhibitors.