Leonit Kiriaev

This study uses iPSC-derived muscle models to show that DUX4 base editing improves muscle function in childhood-onset FSHD.

This study shows that combining ASO targeting CD49d with PMO exon skipping improves muscle function and modulates gene expression in mdx mice, supporting ATL1102 combination therapy for DMD.

This study shows that alpha-actinin-3 deficiency improves cold tolerance through enhanced mitochondrial function and reduced muscle mass loss during acute cold exposure.

This paper refines a radiolabelled assay for measuring glycogen phosphorylase activity in skeletal muscle, revealing sex-specific variations and improving assay reliability across mouse strains.

The study shows that loss of α-actinin-3 in aged mdx dystrophic mice reduces fibre branching and protects against eccentric contraction damage.