The paper identifies a DLX2-regulated gene network that represses Notch signaling and glial fate factors to control neuronal-glial cell fate during forebrain development.

Nature Communications · Aug 20, 2026Peer-reviewedDevelopmental Biology

Efficient installation of heterozygous mutations in human pluripotent stem cells using prime editing

Annabelle Suter, Alison N. Graham, Jia Yi Kuah, Jason Crisologo, Chathuni Gunatilake, Koula Sourris, Michael See, Fernando Jaime Rossello, Mirana Ramialison, Katerina Vlahos, Sara E. Howden

This study demonstrates the use of prime editing to efficiently introduce heterozygous mutations in human pluripotent stem cells with high knock-in efficiency and without purification or selection steps.

The CRISPR Journal · Sep 24, 2025Peer-reviewedCell Biology

Macrophages Mediate Antiviral Immunity and Repair of Type 2 Alveolar Epithelial Cells in a Human Stem Cell Model

Declan L. Turner, Hannah Baric, Katelyn Patatsos, Sahel Amoozadeh, Michael See, Kathleen A. Strumila, Jack T. Murphy, Liam Gubbels, Elizabeth Ng, Andrew G. Elefanty, Melanie R. Neeland, Shivanthan Shanthikumar, Sarah L. Londrigan, Mirana Ramialison, Fernando Jaime Rossello, , Rhiannon B. Werder

This study develops an iPSC-derived air-liquid interface platform to study AT2-macrophage interactions in homeostasis, infection, and repair, revealing their roles in antiviral immunity and epithelial repair.

bioRxiv · Apr 15, 2025 · PreprintCell Biology

ACTN3 genotype influences androgen response in skeletal muscle

Kelly N. Roeszler, Michael See, Lyra R. Meehan, Giscard Humberto Oliveira Lima, Alexander Kolliari-Turner, Sarah E. Alexander, Shanie Landen, Harrison D. Wood, Chrystal F. Tiong, Wei‐Yi Chen, Tomris Mustafa, Peter J. Houweling, Nir Eynon, Séverine Lamon, Yannis Paul Pitsiladis, , Jane T. Seto

This study shows that ACTN3 genotype affects androgen response in skeletal muscle by altering AR expression and pathways related to muscle homeostasis.

bioRxiv · Apr 25, 2024 · PreprintGenetics

The human FLT1 regulatory element directs vascular expression and modulates angiogenesis pathways in vitro and in vivo

Julian S. Stolper, Holly K. Voges, Michael See, Neda R. Mehdiabadi, Gulrez Chahal, Mark Drvodelic, Michael Eichenlaub, Tanya Labonne, Benjamin G. Schultz, Alejandro Hidalgo, Lázaro Centanin, Joachim Wittbrodt, Enzo R. Porrello, David A. Elliott, Mirana Ramialison

The paper identifies a conserved enhancer in the FLT1 locus that drives cardiovascular expression and modulates angiogenesis pathways in vitro and in vivo.

bioRxiv · Mar 3, 2021 · PreprintGenomics