Sam Tallman

This study examines ancestry-related differences in variant prioritisation and diagnostic outcomes in the UK 100,000 Genomes Project, finding disparities in positive predictive value and variant of uncertain significance frequencies across groups.

The paper develops a scalable method to estimate allele ages from large genomic datasets, revealing purifying selection and heterogeneity in ultra-rare variants.

The paper introduces VCF Zarr, a format for efficiently storing and processing large-scale genetic variation data, demonstrating improved performance and scalability over traditional VCF formats.

This study uses whole-genome sequencing of Bantu-speakers from Angola and Mozambique to reveal complex dispersal patterns and interactions in sub-Saharan Africa, including admixture and heterogeneous population histories.