BiochemistrybioRxivPreprint
Unique ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
Inna Rozman Grinberg, Daniel Lundin, Mahmudul Hasan…·Britt-Marie Sjöberg
The paper identifies an ATP-cone in the radical-generating subunit of RNRs, showing it regulates enzyme activity through quaternary structure changes and dATP-induced tetramer formation.
DOI 10.1101/190033