Unique ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
Inna Rozman Grinberg, Daniel Lundin, Mahmudul Hasan, Mikael Crona, Venkateswara Rao Jonna, Christoph Loderer, Margareta Sahlin, Natalia Markova, Ilya Borovok, Gustav Berggren, Anders Hofer, Derek T Logan, Britt-Marie Sjöberg
The paper identifies an ATP-cone in the radical-generating subunit of RNRs, showing it regulates enzyme activity through quaternary structure changes and dATP-induced tetramer formation.
bioRxiv · Sep 17, 2017 · PreprintBiochemistry