Anders Hofer

This study shows that ISG15-USP18 signaling limits viperin-dependent metabolic antiviral restriction by stabilizing USP18 and reducing viperin expression, thereby inhibiting viral replication.

The paper investigates the role of RNase H types 1 and 2 in removing ribonucleotides from the genomes of two archaeal species using combined experimental and sequencing approaches.

This study shows that the AMPK activator A-769662 improves mitochondrial function and partially restores mtDNA levels in cells with mtDNA depletion.

The paper develops a chromatography-free assay to quantify all 12 canonical ribonucleotides in biological samples using real-time fluorogenic detection during in vitro transcription.

This paper demonstrates that a fused glutaredoxin domain in F. ignava NrdB functions as a reductant for RNR via both dithiol and monothiol mechanisms, and shows the ATP-cone's role in regulating enzyme activity through dATP binding.

The paper identifies an ATP-cone in the radical-generating subunit of RNRs, showing it regulates enzyme activity through quaternary structure changes and dATP-induced tetramer formation.