Cell BiologybioRxivPreprint
AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response Proteins
Sasha Friese, Junjie Zai, Grace Luzbetak…·Matthew Shtrahman
This study identifies that rAAV toxicity in dividing cells results from depletion of PARP1 and other DNA damage response proteins, leading to replication stress and cell death.
4 citations