AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response Proteins
Sasha Friese, Junjie Zai, Grace Luzbetak, Nyonika Khanna, Johanna Gesperger, Chien-Hung Liu, Wynand Paul Roos, Rasha Q. Al‐Rahahleh, Matisse Willardson, Feng Yang, Duoduo Fu, Yiming Han, Nadia Lintag, Jaiden Saykham, Joshua Le, , Matthew Shtrahman
This study identifies that rAAV toxicity in dividing cells results from depletion of PARP1 and other DNA damage response proteins, leading to replication stress and cell death.
bioRxiv · Oct 14, 2025 · PreprintCell Biology