Author

Sasha Friese

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Chien-Hung Liu· 1 shared Duoduo Fu· 1 shared Ellen DuongiD· 1 shared Emeen Al-Delaimy· 1 shared Feng YangiD· 1 shared Grace Luzbetak· 1 shared Jaiden Saykham· 1 shared Jeremy N. RichiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Chien-Hung Liu

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1 paper

Recent·Most cited

AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response Proteins

Sasha Friese, Junjie Zai, Grace Luzbetak, Nyonika Khanna, Johanna Gesperger, Chien-Hung Liu, Wynand Paul Roos, Rasha Q. Al‐Rahahleh, Matisse Willardson, Feng Yang, Duoduo Fu, Yiming Han, Nadia Lintag, Jaiden Saykham, Joshua Le, , Matthew Shtrahman

This study identifies that rAAV toxicity in dividing cells results from depletion of PARP1 and other DNA damage response proteins, leading to replication stress and cell death.

bioRxiv · Oct 14, 2025 · PreprintCell Biology