Kai Chen

The paper uses interspecific hybrid embryos to identify EIF1A-family proteins as conserved nuclear regulators of zygotic genome activation across mammals.

The paper studies zygotic genome activation in ascidian hybrids, identifying two waves of gene reactivation and spatial patterns linked to cell mechanics.

This study introduces MISAR-seq to jointly profile spatial gene expression and chromatin accessibility in developing mouse brains, revealing spatiotemporal regulatory principles.

The paper integrates single-cell ATAC and transcriptomic data with spatial transcriptomics to map regulatory features and disease vulnerabilities in macaque cortex.