Chao Liu

Interspecific hybrids reveal a deeply conserved nuclear role of EIF1A-family proteins in zygotic genome activation

The paper uses interspecific hybrid embryos to identify EIF1A-family proteins as conserved nuclear regulators of zygotic genome activation across mammals.

PatientPheX: A Full-Text Biomedical Corpus for Patient-Specific Phenotype Information Extraction

PatientPheX is a biomedical corpus for extracting and normalizing patient-specific phenotype information from full-text articles, achieving high entity and relation extraction performance.

Charting sex divergence in the human brain across the lifespan

This paper constructs sex-specific lifespan brain charts using neuroimaging data from 59,915 individuals, revealing dynamic sex differences in brain development and improving detection of neuropsychiatric abnormalities.

Dual-Binding Scaffold RRsS1 Bridges Pol IV Transcripts and DNA Templates for Robust Reproductive siRNA Biogenesis

This study identifies RRsS1 as a dual-binding scaffold that stabilizes Pol IV transcription complexes to enhance siRNA biogenesis in plant reproduction.

OneGenome-Rice (OGR): A genomic foundation model for rice

OneGenome-Rice (OGR) is a genomic foundation model for rice pre-trained on 422 genomes, outperforming existing models in 11 tasks and enabling downstream applications like trait analysis and gene expression prediction.

Nanosecond laser-driven proton FLASH spares normal tissue cells by sustaining mitochondrial homeostasis and attenuating ferroptosis

This study shows that nanosecond laser-driven proton FLASH-RT spares normal tissue by preserving mitochondrial homeostasis and reducing ferroptosis, while maintaining tumor-killing efficiency.

Separately prestored proteasome components to prevent polyspermy

The paper shows that testis-specific 20S proteasome core particles in sperm help prevent polyspermy by forming chimeric proteasomes that degrade Fetuin B, leading to zona pellucida hardening.

DNAH14 deficiency impairs sperm motility by reducing flagellar beat amplitude

This study identifies DNAH14 as critical for sperm motility by reducing flagellar beat amplitude, and suggests a potential therapeutic approach through increased sperm concentration in IVF.

Functional connectome through the human life span

The paper analyzes functional and structural MRI data from 33,250 individuals to map lifespan changes in the functional connectome, identifying key developmental stages and differences in neurological disorders.

Ccdc38 is required for sperm flagellum biogenesis and male fertility in mouse

The paper shows that CCDC38 is essential for sperm flagellum formation and male fertility in mice, with its deficiency causing structural abnormalities and sterility.

Genomic insights into the population history and biological adaptation of Southwestern Chinese Hmong-Mien people

This study analyzes genome-wide SNPs from Hmong-Mien speakers to reveal genetic substructure, a new ancestral lineage, and adaptive signatures linked to nervous system functions.

Mutations in the catalytic domain of human β-cardiac myosin that cause early onset hypertrophic cardiomyopathy significantly increase the fundamental parameters that determine ensemble force and velocity

This study examines two HCM-causing mutations in human β-cardiac myosin, finding significant increases in actin gliding velocity, intrinsic force, and ATPase activity, indicating a hyper-contractile phenotype.