Benno C. Orr

The paper identifies Kat8 and the NSL complex as essential for lung epithelial repair and maps transcription factor dependencies in alveolar repair trajectories using SAGE.

The paper develops a tool for continuous, long-range, targeted diversification of endogenous mammalian genomes and uses it to explore the function of genetic variants in both coding and non-coding regions.

This paper engineers type V-K CRISPR-associated transposases to improve DNA insertion purity by introducing the HELIX system, achieving 99.3% simple insertion product purity.