Xi Dawn Chen

This paper designs an orthogonal self-labeling protein, LUCI-tag, using deep learning, which enables rapid and payload-agnostic labeling of proteins in live cells.

AlphaGenome Atlas predicts regulatory effects of non-coding variants across the human genome, improving their prioritization and interpretation.

BioVault enables privacy-first biomedical collaboration by allowing analysis code to visit data locally, avoiding data transfer and preserving privacy and data sovereignty.

The paper introduces SPICE, a framework that uses splicing assays and generative design to create cell-specific gene regulation elements for research and therapy.

This study introduces STAG-seq, a method combining transcriptomics and genotyping to functionally analyze genetic variants in immune cells, revealing their impact on gene expression and disease mechanisms.

The paper develops a tool for continuous, long-range, targeted diversification of endogenous mammalian genomes and uses it to explore the function of genetic variants in both coding and non-coding regions.

This study uses synthetic genomes to investigate how synonymous codon recoding affects organismal fitness and develops a workflow to overcome lethal effects of codon swaps.

This paper introduces RADARS, a programmable RNA-sensing technology that uses ADAR-mediated RNA editing to control protein expression based on target RNA transcripts in mammalian cells, with applications in gene therapy and synthetic biology.