João Henrique Diniz Brandão Gervásio

The paper introduces TNP, a computational tool for predicting nanobody developability, calibrated with clinical-stage sequences and experimental data.

This study examines the B cell receptor repertoire and antibody responses after 17DD-YF vaccine boosting, finding a transient antibody response with limited neutralization capacity and rapid clonal expansion of IgA and IgG isotypes.

YClon is a fast and efficient method for clonotyping Ig repertoire data, outperforming existing methods by being 30 to 5000 times faster and handling up to 2 million sequences on a standard laptop.