Graham Charles Walker

Exploiting Peptide Chirality and Transport to Dissect the Complex Mechanism of Action of Host Peptides on Bacteria

This study uses stereochemistry and genetics to distinguish the mechanisms of action of NCR247 on bacterial cells, revealing distinct effects in the periplasm and cytoplasm.

The BacA(SbmA) Importer of Symbiotically Important Legume Nodule Cysteine-Rich Peptides: Insights into Protein Architecture, Function, and Evolutionary Implications

This study investigates the BacA(SbmA) importer in Sinorhizobium meliloti, revealing its role in transporting NCR peptides and explaining why pathogen orthologs can replace BacASm.

Robustness encoded across essential and accessory replicons in an ecologically versatile bacterium

The paper investigates how extrachromosomal replicons in Sinorhizobium meliloti influence gene function and metabolism using Tn-seq and metabolic modeling, revealing widespread genetic interactions and functional dependencies.