Constantine Mylonas

A dual role for H2A.Z.1 in modulating the dynamics of RNA Polymerase II initiation and elongation

This study investigates how H2A.Z.1 modulates RNA Polymerase II dynamics during transcription initiation and elongation in embryonic stem cells, revealing its role in pausing and re-initiation.

Methylation of Q105 on histone H2A is part of a dynamic regulatory mechanism integrating metabolism with ribosome biogenesis through recruitment of Nhp2

The paper identifies H2AQ105 methylation as a chromatin mark integrating metabolic and proliferative signals with ribosome biogenesis through its recognition by Nhp2.

NET-prism enables RNA polymerase-dedicated transcriptional interrogation at nucleotide resolution

NET-prism maps RNA polymerase II and associated factors at single nucleotide resolution, revealing transcriptional dynamics and regulatory complexity.

Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells

This study shows that FACT depletion in mouse embryonic stem cells leads to hyper-proliferation and altered gene expression, linking FACT to chromatin accessibility and cell fate determination.