Peter Tessarz

Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells

This study identifies AMDHD2 as a key regulator linking the hexosamine biosynthetic pathway to acetyl-CoA homeostasis in mouse embryonic stem cells, revealing a metabolic mechanism critical for differentiation.

Dimension Reduction by Spatial Components Analysis Improves Pattern Detection in Multivariate Spatial Data

The paper introduces SPACO, a method for dimension reduction in spatial transcriptomics data that improves pattern detection by maximizing Moran's I and outperforms PCA.

Reduced polymerase pausing compensates for increased chromatin accessibility in the aging liver

The paper identifies age-related changes in chromatin accessibility and transcriptional regulation in murine liver, finding increased accessibility but reduced RNA polymerase pausing.

Methylation of Q105 on histone H2A is part of a dynamic regulatory mechanism integrating metabolism with ribosome biogenesis through recruitment of Nhp2

The paper identifies H2AQ105 methylation as a chromatin mark integrating metabolic and proliferative signals with ribosome biogenesis through its recognition by Nhp2.

The RNA-binding protein Puf5 buffers mRNA levels against chromatin-mediated changes in nascent transcription

The paper shows that Puf5 stabilizes transcripts to buffer mRNA levels against changes in nascent transcription mediated by H3K56A mutation, preventing synthetic lethality.

NET-prism enables RNA polymerase-dedicated transcriptional interrogation at nucleotide resolution

NET-prism maps RNA polymerase II and associated factors at single nucleotide resolution, revealing transcriptional dynamics and regulatory complexity.

Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells

This study shows that FACT depletion in mouse embryonic stem cells leads to hyper-proliferation and altered gene expression, linking FACT to chromatin accessibility and cell fate determination.