Shane Lee

Decoding Dynamically Shifting States of Parkinson's Disease: Tremor, Bradykinesia, and Effective Motor Control

The paper decodes tremor and bradykinesia from subthalamic and cortical recordings in Parkinson's Disease patients, showing distinct neural signatures and varying decoding accuracy based on signal type and location.

Subthalamic-Cortical Network Reorganization during Parkinson's Tremor

This study identifies the neurophysiologic correlates of tremor onset and sustained tremor in Parkinson's disease using intraoperative recordings.

Thalamocortical mechanisms regulating the relationship between transient beta events and human tactile perception

This study investigates how thalamocortical beta events influence tactile perception using MEG and biophysical modeling, finding both suppressive and facilitatory effects depending on timing.

A supragranular nexus for the effects of neocortical beta events on human tactile perception

The paper investigates how neocortical beta events influence tactile perception using MEG and computational modeling, finding that beta events suppress sensory processing through GABAB inhibition.

Biophysical modeling of VIM to assess contributions of oscillatory activity to essential tremor

This paper develops a biophysical model of VIM to investigate how extrinsic and intrinsic oscillatory activity contribute to essential tremor.

Modeling mechanisms of tremor reduction for essential tremor using symmetric biphasic DBS

This paper uses computational modeling to show that symmetric biphasic DBS is more effective than standard DBS at reducing tremor frequency oscillations in the thalamus, with stronger effects on intrinsic networks.