Christopher I. Moore

This paper introduces a modular platform called Interluminescence that uses bioluminescent light to control synaptic transmission by activating optogenetic ion channels in postsynaptic neurons.

This paper proposes a computational model of deviance detection in neocortical circuits based on competitive inhibition between neural ensembles, showing it can encode short-term stimulus memory and explain experimental observations.

The paper introduces BLADe, a platform that converts intracellular activity into photoreceptor activation using bioluminescent sensors and actuators, demonstrating its use in neurons for activity-dependent gene expression and neural dynamics control.

This study investigates how early life adversity in mice affects reward processing and behavior, finding altered dopamine dynamics and behavioral opportunism.

This paper introduces CaBLAM, a bioluminescent Ca2+ indicator with improved dynamic range and Ca2+ affinity, enabling high-resolution imaging of cellular activity in cultured neurons and in vivo.

This study evaluates factors affecting luminopsin efficacy and identifies strategies to improve their function through molecular evolution.

The paper introduces a new bioluminescent optogenetic molecule (LMO7) that enhances chemogenetic activation efficacy compared to existing variants, showing improved neuronal activity modulation and behavioral control.

The paper introduces a method to control synaptically connected neurons using bioluminescent light, validated in cultured neurons and mice.

This study investigates how thalamocortical beta events influence tactile perception using MEG and biophysical modeling, finding both suppressive and facilitatory effects depending on timing.

This study identifies wave-like spatiotemporal patterns in dopamine axons across the dorsal striatum and links them to task contexts and instrumental controllability.

The paper shows that hyperexcitation of specific neocortical neurons during early development causes long-term behavioral and circuit deficits in adulthood.

The paper shows that specific L6 neuron ensembles in mouse somatosensory cortex regulate deviant stimulus encoding and behavioral sensitivity without affecting overall sensory function.

The paper introduces HNN, a software tool that interprets the cellular and network origin of human MEG/EEG data using a neocortical circuit model.

The paper tests the relationship between bioluminescent photon emission and optogenetic effects in neocortex using BL-OG molecules and Coelenterazine doses.

The paper investigates how neocortical beta events influence tactile perception using MEG and computational modeling, finding that beta events suppress sensory processing through GABAB inhibition.

The paper shows that the rate of transient high-power beta events in brain signals predicts impaired function across human and mouse tasks.