Developmental BiologyPLoS ONEPeer-reviewed
Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site.
Stuart J. Smith, Norma Towers, Kim Demetriou, Timothy J. Mohun
This study shows that knocking out Adprhl1 in Xenopus leads to heart chamber growth defects and myofibril assembly failure, revealing a critical role for a non-catalytic substrate binding site in cardiac development.