Application of mechanistic methods to clinical trials in multiple sclerosis: the simvastatin case
Arman Eshaghi, Rogier Kievit, Ferrán Prados, Carole H. Sudre, Jennifer M. Nicholas, M. Jorge Cardoso, Dennis Chan, Richard S. Nicholas, Sebastien Ourselin A, John Greenwood, Alan J. Thompson, Daniel C. Alexander, Frederik Barkhof, Jeremy Chataway, Olga Ciccarelli
The paper applies multivariate mechanistic models to a clinical trial in multiple sclerosis to investigate pathways linking simvastatin to clinical outcomes.
Proceedings of the National Academy of Sciences · May 9, 2019Peer-reviewedNeuroscience