Dennis Chan

This paper introduces an automated method to quantify white matter hyperintensity confluence, showing it correlates with cognitive performance and dementia subtypes beyond volume.

This study shows that disrupted hippocampal reactivations in AD mice predict spatial memory deficits by reducing place cell stability.

The paper identifies immune signatures predicting changes in neural circuit activity in a mouse Alzheimer's model.

This study shows iPSC-derived astrocytes from AD patients reflect key pathophysiological features, offering a new model for AD research and therapeutic screening.

This study identifies an Alzheimer's disease-specific cytokine signature that suppresses mitochondrial function in neurons, linking neuroinflammation to metabolic dysfunction.

The paper shows that midlife path integration impairments predict Alzheimer's disease risk, independent of other cognitive tests.

The paper uses induced pluripotent stem cell-derived cortical neurons from early Alzheimer's patients to show that cellular vulnerability to amyloid-beta correlates with clinical vulnerability.

This study shows that APOE4 astrocytes increase neuronal metabolic stress in the presence of amyloid-β compared to APOE3 astrocytes.

The paper applies multivariate mechanistic models to a clinical trial in multiple sclerosis to investigate pathways linking simvastatin to clinical outcomes.

This study uses a virtual reality navigation task to differentiate mild cognitive impairment patients with and without Alzheimer's disease biomarkers, showing higher accuracy than standard cognitive tests.