Shu Wang

The paper uses CERAMIC to trace liver tumor initiation, identifying Hep_Bi-zonal cells as the origin of HCC and ICC and revealing peroxisomal metabolism and macrophage niches as key factors.

This paper develops ProAPOBECs, engineered cytidine deaminases fused with PUF proteins, for effective RNA base editing in the brain, correcting mutations and reducing autistic-like behaviors in mice.