Wenjian Han

This paper develops ProAPOBECs, engineered cytidine deaminases fused with PUF proteins, for effective RNA base editing in the brain, correcting mutations and reducing autistic-like behaviors in mice.

This paper develops artificial RNA endonucleases (ARCs) that specifically degrade toxic RNA expansions in DM1, showing efficacy in cells and mouse models with low immunogenicity and off-target effects.

This paper demonstrates whole-brain in vivo base editing in mice to reverse autistic-like behaviors by correcting a mutation in the MEF2C gene.