Targeting the 3D genome by anthracyclines for chemotherapeutic effects
Minkang Tan, Shengnan Sun, Yuchen Liu, Andrea A. Perreault, Douglas H. Phanstiel, Liping Dou, Baoxu Pang
This study shows anthracycline drugs disrupt 3D chromatin structure by interfering with CTCF binding, altering gene regulation and clinical outcomes in AML.
Proceedings of the National Academy of Sciences · Oct 3, 2025Peer-reviewedCancer Biology