BiochemistrybioRxivPreprint
Pre-catalytic activation pathway of the Smc5/6 complex
Jan Siu Kei Wong, Mun Siong Loke, Biswajit Pradhan…·Eugene Kim
This study defines the pre-catalytic activation pathway of the Smc5/6 complex using cryo-EM and conformational analysis, revealing a structural transition from Bridge to Engaged states.
DOI 10.64898/2026.10.09.757879