Author

Jan Fabio Nickels

German Cancer Research CenterORCID 0000-0001-7371-1784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1

Frequent Co-Authors

Anne RademacheriD· 1 shared Arjun UdupaiD· 1 shared Caroline KnotziD· 1 shared Karsten RippeiD· 1 shared Kim SneppeniD· 1 shared Lukas FrankiD· 1 shared Robin WeinmanniD· 1 shared Tsz Ching Chloe Tang· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Anne RademacherORCID

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2 papers

Recent·Most cited

Cell BiologyMolecular CellPeer-reviewedSep 1, 2026

HP1 binding creates a local barrier against transcription activation and persists during chromatin decondensation

Robin Weinmann, Arjun Udupa, Jan Fabio Nickels…·Karsten Rippe

The paper investigates how HP1 binding represses transcription at chromocenters and persists during decondensation, using a 1D lattice model to explain chromatin state transitions.

1 citation

𝕏 PostBluesky

GenomicsbioRxivPreprintDec 20, 2022

Theoretical analysis of confinement mechanisms for epigenetic modifications of nucleosomes

Jan Fabio Nickels, Kim Sneppen

The paper analyzes confinement mechanisms for epigenetic modifications of nucleosomes using stochastic dynamic models and finds that intermediate states and long-range negative feedback enhance robustness and confinement.

1 citation

statistical model

𝕏 PostBluesky