Lukas Frank

Gene context shapes spatial organization and transcriptional heterogeneity of extrachromosomal DNA in cancer cells

This study investigates how gene context influences the spatial organization and transcriptional behavior of extrachromosomal DNA in cancer cells using a new imaging method called FLAGx.

HP1 binding creates a local barrier against transcription activation and persists during chromatin decondensation

The paper investigates how HP1 binding represses transcription at chromocenters and persists during decondensation, using a 1D lattice model to explain chromatin state transitions.

Visualizing homology search in living cells

This study visualizes homology search dynamics in living human cells using GFP-MND1, revealing filament structures that resolve over time and depend on RAD54L and cohesin.

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus

This study identifies MeCP2's role in regulating alternative splicing in the mouse hippocampus during spatial learning and shows its impact on memory consolidation and Rett syndrome pathophysiology.