Anne Rademacher

The paper investigates how HP1 binding represses transcription at chromocenters and persists during decondensation, using a 1D lattice model to explain chromatin state transitions.

The paper identifies two chromatin modules, ACs and DCs, that regulate proinflammatory gene expression through distinct mechanisms in human endothelial cells.

This study compares four spatial transcriptomics technologies for analyzing medulloblastoma cryosections, highlighting their strengths and providing guidance for method selection.

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

The paper develops a chromatin hierarchical lattice framework to predict heterochromatin nanodomains and identifies DNA sequence and protein binding factors that determine their formation and boundaries.