Hao Zhu

The paper identifies lineage-specific lncRNAs that drive cross-species differences in tumors and shows their impact on drug efficacy and cancer immunity.

The paper identifies human-specific lncRNAs and shows they have significantly reshaped gene expression in the brain compared to human-specific transcription factors.

The paper identifies erroneous noncoding transcripts in cancer cells and shows they can specifically regulate cancer-related genes and pathways, suggesting new therapeutic targets.

msCNVS enables efficient CNV profiling of rare clinical samples through barcoded single-cell library construction without preamplification.

The paper identifies lineage-specific lncRNAs in human and mouse genomes, showing their strong association with transposable elements and their impact on transcriptional regulation.

CausalCell applies causal discovery to single-cell data to infer causal interactions, addressing challenges in algorithm design and evaluation for this task.

PopTradeOff integrates favored mutations, GWAS sites, and drug response variants to explore population-specific links between adaptive evolution, disease susceptibility, and drug responsiveness.