Xinghua Pan

This study identifies cortactin's role in suppressing mTOR-dependent senescence in CTCs, leading to metastatic dormancy, and proposes a therapeutic strategy combining cortactin depletion and senolytics.

msCNVS enables efficient CNV profiling of rare clinical samples through barcoded single-cell library construction without preamplification.

The paper introduces msRRBS, a scalable single-cell methylation sequencing method, achieving high read mapping rates and cost efficiency for analyzing methylation patterns in multiple cell lines and cancer models.