Author

Kosuke Iwai

Sandia National Laboratories CaliforniaORCID 0000-0001-7395-3521Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Abi Ramanan· 1 shared Aindrila MukhopadhyayiD· 1 shared Anup K. SinghiD· 1 shared Charlie A. Emrich· 1 shared Chenling A. XuiD· 1 shared David Ando· 1 shared David BelangeriD· 1 shared Hanson LeeiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Abi Ramanan

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2 papers

Recent·Most cited

BioinformaticsCell SystemsPeer-reviewedMar 1, 2025

Engineering of highly active and diverse nuclease enzymes by combining machine learning and ultra-high-throughput screening

Neil Thomas, David Belanger, Chenling A. Xu…·Lucy J. Colwell

This study combines machine learning and high-throughput screening to design improved nuclease enzymes, finding a more effective variant than standard directed evolution methods.

39 citationstop 1%

protein sequencemachine learning (classical)

𝕏 PostBluesky

Synthetic BiologyMicrosystems & NanoengineeringPeer-reviewedMar 15, 2022

Scalable and Automated CRISPR-Based Strain Engineering Using Droplet Microfluidics

Kosuke Iwai, Maren Wehrs, Megan E. Garber…·Anup K. Singh

The paper describes a microfluidic system for high-throughput CRISPR-based gene editing and screening, demonstrating its ability to perform parallel genetic modifications in E. coli.

39 citations

E. coliCRISPR screen

𝕏 PostBluesky