Jörg H. W. Distler

This study identifies spatially distinct fibroblast subpopulations and niches in human myocardial fibrosis across different disease states and their associations with fibrotic remodeling and cardiac dysfunction.

This study shows reduced mitochondrial ketone body oxidation in insulin resistant states across multiple organs in humans and mice.

The paper identifies a unique myeloid precursor population that facilitates the spread of psoriatic inflammation from skin to joints, interacting with fibroblasts to regulate T cell IL-17 expression.

The paper uses spatial transcriptomic methods to identify novel fibroblast subpopulations in systemic sclerosis skin and their pathogenic roles.

The paper maps the metabolic landscape of skin fibrosis in systemic sclerosis using single-cell analysis and identifies metabolically active cell types and their interactions.

The paper maps spatially-resolved transcriptomes in systemic sclerosis to identify a fibrotic niche and disease-specific cell states, linking them to clinical outcomes.