Molecular BiologybioRxivPreprint
Discovery of conformation-sensitive anti-amyloid protofibril monoclonal antibodies using an engineered chaperone-like amyloid-binding protein
W. Vallen Graham, Alessandra Bonito-Oliva, Rita Agostinelli…·Thomas P. Sakmar
This paper describes a method to stabilize A{beta} protofibrils using an engineered chaperone-like protein, enabling the discovery of conformation-sensitive anti-A{beta} monoclonal antibodies that target protofibrils over monomers or plaques.
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