Novel lentiviral constructs for the specification of rare and ectopic cell types in human colonoids.
Priti Prasanna Maity, Na Qu, Jorge O. Múnera
This study develops lentiviral constructs to induce specific epithelial cell types in human colonoids, revealing that KLF4 can generate goblet cells and colonocytes, while NEUROG3 and NKX6-3 induce duodenal enteroendocrine subtypes.
bioRxiv · Oct 16, 2025 · PreprintCell Biology