Jorge O. Múnera

This study shows NEUROG3 can drive neuroendocrine differentiation in prostate cancer cells, identifying it as a potential mediator of cancer progression.

This study develops lentiviral constructs to induce specific epithelial cell types in human colonoids, revealing that KLF4 can generate goblet cells and colonocytes, while NEUROG3 and NKX6-3 induce duodenal enteroendocrine subtypes.

This study shows that loss of WNT2B promotes colorectal cancer progression in mouse models and is associated with poor patient survival in human samples.

This study uses human pluripotent stem cell-derived hindgut cultures to show that WNT signaling directs dorsal-ventral patterning, promoting urothelial fate over colorectal fate.