Lena Maria Hackl

This study evaluates whether sequence-based tools can detect alternative splicing from low-depth RNA-seq data, showing promise for hypothesis generation but limitations in de novo detection.

The paper introduces NeEDL, a network medicine-based method for detecting higher-order epistatic interactions in complex diseases, showing improved statistical significance and applicability across eight diseases.

The paper investigates how alternative splicing affects miRNA regulation by analyzing six TCGA cancer datasets, finding that transcripts with miRNA target sites in coding regions better predict miRNA expression.