Sabine Ameling

Detection of alternative splicing: deep sequencing or deep learning?

This study evaluates whether sequence-based tools can detect alternative splicing from low-depth RNA-seq data, showing promise for hypothesis generation but limitations in de novo detection.

Regulation of the transcriptome, miRNAs, and alternative splicing in a FSGS zebrafish injury model

This study investigates alternative splicing and miRNA regulation in a zebrafish FSGS model, identifying key splicing events and miRNAs associated with disease progression.

Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertension

The paper investigates alternative splicing in mechanically stretched podocytes, identifying splicing events in Shroom3 and Myl6 that may contribute to hypertensive nephropathy.

RNA sequencing depth guidelines for the study of alternative splicing

The paper provides sequencing depth guidelines for comprehensive alternative splicing analysis across tissues, showing that current depths are insufficient and recommending deeper sequencing or long-read technologies.