Jaakko T. Leinonen

The paper identifies PE-dependent genetic regulation at promoters using cis-eQTL analysis of placental RNA sequencing data from the FINNPEC cohort.

Phenome-wide scan of Y-chromosomal variants against 1,426 traits in 104,334 Finnish men finds no significant hits; kin-based validation supports haplogroup I1 increasing coronary heart disease risk.

This study identifies maternal and fetal genetic contributions to preeclampsia through genome-wide association analyses, revealing distinct genetic architectures and biological pathways.

The paper examines sex biases in the human brain transcriptome across development and adulthood, finding that many sex differences originate in the prenatal period and persist into adulthood.

This paper introduces a Y-chromosomal ancestral-like reference sequence (Y-ARS) to improve the detection of evolutionarily informative variants on the human Y chromosome, showing it captures more consistent and derived variants compared to existing references.

The study analyzes Y-chromosome sequencing data from Finland to identify sublineages and geographic patterns within major haplogroups, suggesting dual migration routes for haplogroup N1a1.

The paper uses Mendelian Randomization to assess the causal link between maternal influences on birth weight and five health outcomes in 36,211 genotyped mother-child pairs.

This study uses genetic data to examine testosterone's effects on health, finding sex-specific impacts on female reproductive health and complex associations with disease risk.